MicroRNA-145 Targeted Therapy Reduces Atherosclerosis
نویسندگان
چکیده
منابع مشابه
MicroRNA-145 targeted therapy reduces atherosclerosis.
BACKGROUND MicroRNA are essential posttranscriptional modulators of gene expression implicated in various chronic diseases. Because microRNA-145 is highly expressed in vascular smooth muscle cells (VSMC) and regulates VSMC fate and plasticity, we hypothesized that it may be a novel regulator of atherosclerosis and plaque stability. METHODS AND RESULTS Apolipoprotein E knockout mice (ApoE(-/-)...
متن کاملLDL-receptor-deficient mice lacking microRNA-143/145 have less atherosclerosis.
MicroRNAs (miRNAs, miRs) have emerged as important post-transcriptional regulators of gene expression. In vascular pathologies, the miR-143/145 cluster has attracted particular attention. The miR-143/145 cluster is encoded by a bicistronic transcript, and regulates the differentiation, plasticity and contractile function of vascular smooth muscle cells (VSMCs). VSMCs from miR143/145–deficient m...
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Patients with lung adenocarcinoma may benefit from recently developed molecular targeted therapies. However, analogous advanced treatments are not available for patients with lung squamous cell carcinoma (lung SCC). The survival rate of patients with the advanced stage of lung SCC remains poor. Exploration of novel lung SCC oncogenic pathways might lead to new treatment protocols for the diseas...
متن کاملMicroRNA-143/-145 in Cardiovascular Diseases
MicroRNAs (miRNAs) play an essential role in the onset and development of many cardiovascular diseases. Increasing evidence shows that miRNAs can be used as potential diagnostic biomarkers for cardiovascular diseases, and miRNA-based therapy may be a promising therapy for the treatment of cardiovascular diseases. The microRNA-143/-145 (miR-143/-145) cluster is essential for differentiation of v...
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BACKGROUND Epigenetic factors, such as microRNAs, are important regulators in the self-renewal and differentiation of stem cells and progenies. Here we investigated the microRNAs expressed in human limbal-peripheral corneal (LPC) epithelia containing corneal epithelial progenitor cells (CEPCs) and early transit amplifying cells, and their role in corneal epithelium. METHODOLOGY/PRINCIPAL FIND...
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ژورنال
عنوان ژورنال: Circulation
سال: 2012
ISSN: 0009-7322,1524-4539
DOI: 10.1161/circulationaha.111.084186